Abstract We conduct a numerical investigation of fiber-based entanglement distribution over distances of up to 1600 km using a chain of processing-node quantum repeaters. We determine minimal hardware requirements while simultaneously optimizing over protocols for entanglement generation and entanglement purification, as well as over strategies for entanglement swapping. Notably, we discover that through an adequate choice of protocols the hardware improvement cost scales linearly with the distance covered. Our results highlight the crucial role of good protocol choices in significantly reducing hardware requirements, such as employing purification to meet high-fidelity targets and adopting a swap as soon as possible policy for faster rates. To carry out this analysis, we employ an extensive simulation framework implemented with NetSquid, a discrete-event-based quantum-network simulator, and a genetic-algorithm-based optimization methodology to determine minimal hardware requirements.