Structural Basis for Membrane Anchorage of Viral ϕ29 DNA during Replication

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2005 English Publisher:Elsevier BVJournal:Journal of Biological Chemistry, volume 280, pages 42,486-42,488 (issn: 0021-9258,

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Authors: Albert, Armando; Muñoz-Espín, D.; Jiménez, Marta; Asensio, Juan Luis; Hermoso, José Miguel; Salas, Margarita; Meijer, Wilfried J. J.;

doi: 10.1074/jbc.c500429200

pmid: 16275651

handle: 10261/37725

Structural Basis for Membrane Anchorage of Viral ϕ29 DNA during Replication

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Abstract

Prokaryotic DNA replication is compartmentalized at the cellular membrane. Functional and biochemical studies showed that the Bacillus subtilis phage 29-encoded membrane protein p16.7 is directly involved in the organization of membrane-associated viral DNA replication. The structure of the functional domain of p16.7 in complex with DNA, presented here, reveals the multimerization mode of the protein and provides insights in the organization of the phage genome at the membrane of the infected cell.

Related Organizations

Spanish National Research Council
Spain
Centro de Biología Molecular Severo Ochoa
Spain
Autonomous University of Madrid
Spain
Institute of Physical Chemistry "Rocasolano"
Spain

Keywords

DNA Replication, Models, Molecular, Protein Conformation, Membrane Proteins, Genome, Viral, Crystallography, X-Ray, Protein Structure, Secondary, Protein Structure, Tertiary, Viral Proteins, DNA, Viral, Bacteriophages, Dimerization, Bacillus subtilis

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