Cobalt-catalysed reductive C–H alkylation of indoles using carboxylic acids and molecular hydrogen

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2017Embargo end date: 27 Apr 2023 Spain English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Science, volume 8, pages 6,439-6,450 (issn: 2041-6520, eissn: 2041-6539,

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Authors: Jose R. Cabrero-Antonino; Rosa Adam; Kathrin Junge; Matthias Beller;

doi: 10.1039/c7sc02117h , 10.34657/11121

pmid: 29163930

pmc: PMC5632795

handle: 10261/375620

Cobalt-catalysed reductive C–H alkylation of indoles using carboxylic acids and molecular hydrogen

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Abstract

The first direct CH-alkylation of indoles using carboxylic acids and hydrogen is presented. A non-noble metal based catalytic system, [Co(acac)3/Triphos/Al(OTf)3], efficiently catalyses the alkylation of a variety of indoles with a wide range of carboxylic acids.

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Spain

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Keywords

Alkylation, Catalysts, Alkenylation, Carboxylic acids, Functionalizations, Reductive alkylation, 540, Non-precious metals, Reaction conditions, Polycyclic aromatic hydrocarbons, Chemistry, Control experiments, Molecular hydrogen, Substituted indoles, Indole derivatives

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