Uncatalyzed Strecker‐Type Reaction of N,N‐Dialkylhydrazones in Pure Water

descriptionPublicationkeyboard_double_arrow_right Article 23 Jun 2008 Spain English Publisher:WileyJournal:European Journal of Organic Chemistry, volume 2,008, pages 3,457-3,460 (issn: 1434-193X, eissn: 1099-0690,

Copyright policy )

Authors: Marqués-López, Eugenia; Herrera, Raquel P.; Fernández, Rosario; Lassaletta, José M.;

doi: 10.1002/ejoc.200800297

handle: 10261/37218

Uncatalyzed Strecker‐Type Reaction of N,N‐Dialkylhydrazones in Pure Water

- Summary
- Subjects
- Metrics

Abstract

AbstractAldehyde and ketone N,N‐dialkylhydrazones behave as a stable class of imine surrogates exhibiting a unique reactivity in the Strecker reaction with in situ generated HCN, that proceeds in pure water in the absence of co‐solvents, catalysts or promoters. Experimental evidence suggests that the reaction is assisted by an intramolecular activation of HCN by the dialkyl amino lone pair.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Country

Spain

Related Organizations

Keywords

Synthetic methods, Hydrazino nitriles, Hydrazones, Water, Nucleophilic addition

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	14
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%