Gene silencing mediated by magnetic lipospheres tagged with small interfering RNA
Gene silencing mediated by magnetic lipospheres tagged with small interfering RNA
Lipospheres made from soy bean oil and a combination of the cationic lipid Metafectene and the helper lipid dioleoylphosphatidyl-ethanolamine were functionalized with magnetic nanoparticles (NPs) and small interfering RNA (siRNA). The resulting magnetic lipospheres loaded with siRNA are proven here as efficient nonviral vectors for gene silencing. Embedding magnetic NPs in the shell of lipospheres allows for magnetic force-assisted transfection (magnetofection) as well as magnetic targeting in both static and fluidic conditions mimicking the bloodstream.
This work was supported by the BMBF/ERA-NET NEURON (project NanoSyn to W.J.P.) and by the Nanobiotechnology program (www.nanobio.de) of the German Federal Ministry of Education and Research (Grants 13N8186 and 13N8538 to C.P.). Financial support (to C.P.) from the German Excellence Initiative via the “Nanosystems Initiative Munich (NIM)” is also gratefully acknowledged.
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