To compare the color dimensions, color discrepancies (ΔE00), and surface roughness of milled materials before and after the application of a bleaching agent.A total of 10 extracted molars were obtained. Each tooth was cut in transversal sections, to create discs (3 mm thick, 10 mm diameter) (control group). Disk specimens of 8 materials were fabricated: polymethyl methacrylate (PMMA) interim material (PMMA-Telio group), 2 resin nanoceramics: (RNC-Ultimate group) and (RNC-Cerasmart group), 2 hybrid ceramics: (HC-Shofu group) and (HC-Enamic group), lithium disilicate (LD-Emax group), zirconia reinforced glass ceramic (ZGC-Suprinity group), and zirconia (Zr group) (n=10). Color measurements were obtained using a spectrophotometer before and after applying 35% hydrogen peroxide-based bleaching agent. Pre- and post-bleaching surface roughness analysis were completed using a profilometer.Significant L*, a*, b*, and ΔE00 values differences were found (P < .05). Color discrepancies (ΔE00) ranged from 0.30 ± 0.14 to 4.82 ± 0.10. The highest color discrepancies were measured on the PMMA-Telio group, while the lowest color discrepancies were computed on the ZGC-Suprinity, RNC-Ultimate, and RNC-Cerasmart. Significant surface roughness differences were found (P <.05). The largest increase of surface roughness values between the pre- and post-bleaching measurements was obtained in the PMMA-Telio group with a mean ΔSa value of 4.73 ± 3.02, while the largest decrease of surface roughness values between the pre- and post-bleaching measurements was obtained in the Zr-InCeram group with a mean ΔSa value of -1.58 ± 0.10.The milled materials tested showed significant pre- and post-bleaching color and surface roughness discrepancies. Int J Prosthodont. doi: 10.11607/ijp.8359.