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Dissecting the role of the thalamus in neuropsychiatric disorders requires new models to analyze complex genetic interactions. In this issue of Cell Stem Cell, Shin et al. use patient-derived thalamocortical organoids to investigate 22q11.2 microdeletion impact on thalamic development, revealing significant transcriptional dysregulation linked to psychiatric disorders.
Cerebral Cortex, Organoids, Thalamus, thalamus in neuropsychiatric disorders, Mental Disorders, Neural Pathways, Humans, transcriptional dysregulation
Cerebral Cortex, Organoids, Thalamus, thalamus in neuropsychiatric disorders, Mental Disorders, Neural Pathways, Humans, transcriptional dysregulation
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