Hepatic steatosis after switching to integrase inhibitor-based regimens does not parallel short-term weight gain

descriptionPublicationkeyboard_double_arrow_right Article 26 Oct 2023 English Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:AIDS, volume 37, pages 2,259-2,262 (issn: 0269-9370, eissn: 1473-5571,

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Authors: González-Serna Martín, Manuel Alejandro; Macías Sánchez, Juan; Rincón, Pilar; Arriaza, María José; Corma-Gómez, Anais; Santos, Marta; Fernández-Fuertes, Marta; +2 Authors

doi: 10.1097/qad.0000000000003673

pmid: 37877283

handle: 10261/350664 , 11441/167736

Hepatic steatosis after switching to integrase inhibitor-based regimens does not parallel short-term weight gain

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Abstract

We studied hepatic steatosis in people with HIV (PWH) who switched to an integrase inhibitor (INSTI)-based regimen. One hundred and fifty-four PWH were included. After 48 weeks, median (Q1–Q3) weight gain was 1.2 (−0.6 to 3.8) kg and median (Q1–Q3) controlled attenuation parameter (CAP) change was −4 (−33 to 27) dB/m. Weight gain was weakly correlated with CAP change [R 2 95% confidence interval (CI) = 0.144 (−0.014 to 0.296); P = 0.074)]. Changes in hepatic steatosis after switching to INSTI-based regimens do not seem to parallel weight gain after 1 year.

Related Organizations

CENTRO DE INVESTIGACION BIOMEDICA EN RED
Spain
University of Seville
Spain
Spanish National Research Council
Spain
Institute of Biomedicine of Seville
Spain
Hospital Universitario de Valme
Spain

Keywords

Fatty Liver, Humans, Elasticity Imaging Techniques, HIV Infections, HIV Integrase Inhibitors, Weight Gain

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