New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2006 English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 16, pages 1,392-1,396 (issn: 0960-894X,

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Authors: Alonso De Diego, Sergio A.; Gutiérrez-Rodríguez, Marta; Pérez de Vega, M. Jesús; Casabona, Diego; Cativiela, Carlos; González-Muñiz, Rosario; Herranz, Rosario; +5 Authors

doi: 10.1016/j.bmcl.2005.11.040

pmid: 16321525

handle: 10261/33944

New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity

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Abstract

A suitable solid-phase approach, based on Fmoc/(t)Bu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.

Related Organizations

University of Navarra
Spain
University of Zaragoza
Spain
Instituto de Química Médica
Spain
Chartered Institute of Management Accountants
United Kingdom
Spanish National Research Council
Spain

Keywords

N-Methylaspartate, Solid-phase synthesis, Molecular Structure, GPE analogues, Hippocampus, Rats, Structure-Activity Relationship, Neuroprotective Agents, Neuroprotective activity, Receptors, Glutamate, Animals, Amino Acid Sequence, Peptides, Cells, Cultured, Triphenylmethyl Compounds

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