Synthesis and analgesic properties of N‐phosphorylated derivatives of Phe‐Ala and Phe‐Gly

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1985 English Publisher:WileyJournal:International Journal of Peptide and Protein Research, volume 26, pages 174-178 (issn: 0367-8377,

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Authors: García-López, M. Teresa; González-Muñiz, Rosario; Herranz, Rosario; Bravo, H,; Naranjo, José Ramón; Río, Joaquín del;

doi: 10.1111/j.1399-3011.1985.tb03194.x

pmid: 4066153

handle: 10261/336591

Synthesis and analgesic properties of N‐phosphorylated derivatives of Phe‐Ala and Phe‐Gly

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Abstract

N‐Phosphoryl dipeptides derived from Phe‐Ala, Phe‐Ala‐NH2 and Phe‐Gly‐NH2 were synthesized and their analgesic activity was evaluated in mice. Intracere‐broventricular administration of P‐Phe‐Ala‐NH2 produced a 100‐fold increase in the analgesic potency of Phe‐Ala and led to a potentiation and prolongation of the analgesic effect of the exogenously administered Met‐enkephalin.

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Keywords

Male, Phosphopeptides, Analgesics, Mice, Inbred ICR, Alanine, Phenylalanine, Glycine, Dipeptides, Mice, Structure-Activity Relationship, Animals, Biological Assay, Analgesia

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