Analgesic dipeptide derivatives.

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1987 English Publisher:WileyJournal:International Journal of Peptide and Protein Research, volume 29, pages 613-620 (issn: 0367-8377,

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Authors: García-López, M. Teresa; González-Muñiz, Rosario; Herranz, Rosario; Molinero, M. Teresa; Río, Joaquín del;

doi: 10.1111/j.1399-3011.1987.tb02291.x

pmid: 3610476

handle: 10261/335961

Analgesic dipeptide derivatives.

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Abstract

The syntheses of dipeptide derivatives of the general formula X‐Trp(Nps)‐OR (R = H or Me; X = Lys, Gly, Ala, Leu, Ser, Glu, His, Arg, Orn, Dpr, Gpr and Har) are described. The analgesic activities of Gpr‐ and Har‐containing dipeptides have been evaluated and, in the light of these results, the influence of the side chain length of the basic amino acid on the analgesic effect is studied.

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Keywords

Analgesics, Magnetic Resonance Spectroscopy, Tryptophan, Dipeptides, Mice, Structure-Activity Relationship, Animals, Indicators and Reagents, Spectrophotometry, Ultraviolet, Chromatography, Thin Layer, Analgesia

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