The interaction between an opioid antagonist, naloxone, and several lipids and lipid mixtures was studied using monomolecular layers as a membrane model. No specific interactions could be detected. The main factor affecting the penetration of naloxone in monolayers seems to be the initial ordered state of the molecules instead of the chemical composition of the monolayer. A new membrane model was assayed based on the retention times in high-pressure liquid chromatography working with hydrophobically modified columns.

Peer reviewed