Ethylmorphine-lipid interaction study by calorimetry and monolayer techniques

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1988 Italy, Spain English Publisher:Elsevier BVJournal:Thermochimica Acta, volume 130, pages 221-228 (issn: 0040-6031,

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Authors: CASTELLI, Francesco; REIG F; GARCIAANTON JM; ALSINA MA; BUSQUETS A; VALENCIA G.;

doi: 10.1016/0040-6031(88)87068-0

handle: 10261/331848 , 20.500.11769/27780

Ethylmorphine-lipid interaction study by calorimetry and monolayer techniques

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Abstract

Liposomes and monolayers were used as membrane models to examine the interaction of lecithin and the opioid agonist ethylmorphine. By calorimetric measurements, the ability of the drug to increase the fluidity of the lipid has been explained by electrostatic interaction between the drug and the polar headgroup of the lipid. Compression isotherms and penetration kinetics of the lipid monolayers in the presence of the drug confirmed the previous observations.

This work was partly supported by a NATO grant for international cooperative research.

Peer reviewed

Countries

Italy, Spain

Related Organizations

Spanish National Research Council
Spain
University of Catania
Italy

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