Total synthesis of C37 alken-2-one temperature geomarkers

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2023 Spain, Spain English Publisher:Elsevier BVJournal:Tetrahedron Letters, volume 123, page 154,571 (issn: 0040-4039,

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Authors: Anna Alcaide; Carme Serra; Juanlo Catena; Lourdes Muñoz; Amadeu Llebaria;

doi: 10.1016/j.tetlet.2023.154571

handle: 10261/329463

Total synthesis of C37 alken-2-one temperature geomarkers

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Abstract

The total synthesis of the natural (8E,15E,22E)-heptatriaconta-8,15,22-trien-2-one and (15E,22E)-heptatriaconta-15,22-dien-2-one is reported. Our synthesis involved a modular and convergent approach, based on the copper-catalyzed addition of Grignard reagents to allylic olefins. The obtention of these methyl ketones is an important asset for the use of these compounds as analytical patterns with application in Earth sciences.

We gratefully acknowledge the Geochemistry and Pollution Research Group from the Institute of Environmental Assessment and Water Research (IDAEA-CSIC) and CSIC (201980E011) for financial support.

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Spain, Spain

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Keywords

Paleoclimate indicators, Total synthesis, http://metadata.un.org/sdg/3, Ensure healthy lives and promote well-being for all at all ages, Long-chain alkenones

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