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Use of peptides of the E1 protein of the hepatitis G virus in order to inhibit the activity of the HIV virus

Authors: Haro Villar, Isabel; Gómara Elena, María José;

Use of peptides of the E1 protein of the hepatitis G virus in order to inhibit the activity of the HIV virus

Abstract

[EN] The invention relates to the use of peptides of the E1 protein of the hepatitis G virus in order to inhibit the activity of the HIV virus. More specifically, the invention relates to the use of at least one peptide, or a derivative of same, contained in the sequence of the E1 protein of the hepatitis G virus (GBV-C/HGV), capable of inhibiting the activity of the HIV virus, impeding or repressing the function and/or activity of the HIV virus (human immunodeficiency virus), in a temporary or permanent manner, or additionally capable of interacting with an amino acid sequence of glycoprotein gp41 of the HIV virus, for the production of a pharmaceutical composition. Said peptide can impede the inhibition of the function of the fragment of protein gp41 of the HIV virus, impede cell fusion or impede the replication of HIV in a host cell. In addition, the invention relates to the aforementioned pharmaceutical composition and to the method for the production thereof.

[ES] La presente invención se refiere al uso de al menos un péptido, o derivado del mismo, contenido en la secuencia de la proteína E1 del virus de la hepatitis G (GBV-C/HGV), capaz de inhibir la actividad del virus VIH, impidiendo o reprimiendo la función y/o actividad del virus VIH (Virus de Inmunodeficiencia Humana), de forma transitoria o permanente, o además capaz de interaccionar con una secuencia aminoacídica de la glicoproteína gp41 del virus VIH, para la elaboración de una composición farmacéutica. Dicho péptido es capaz de impedir la inhibición de la función del fragmento de la proteína gp41 del virus VIH, impedir la fusión celular o impedir la replicación del VIH en una célula huésped. Asimismo la presente invención también se refiere a dicha composición farmacéutica y al método para su fabricación.

A1 Solicitud de patente con informe sobre el estado de la técnica

Consejo Superior de Investigaciones Científicas (España)

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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