A Concise Synthesis of a Trehazolamine Epimer with Moderate α-Mannosidase Inhibitory Activity Starting from d-Mannose

descriptionPublicationkeyboard_double_arrow_right Article 31 Dec 1999 Spain English Publisher:Georg Thieme Verlag KGJournal:Synlett, volume 1,999, pages 1,551-1,554 (issn: 0936-5214, eissn: 1437-2096,

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Authors: Bobo, Sofía; Storch, Isabel; Chiara, José Luis;

doi: 10.1055/s-1999-3168

handle: 10261/30938

A Concise Synthesis of a Trehazolamine Epimer with Moderate α-Mannosidase Inhibitory Activity Starting from d-Mannose

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Abstract

A concise synthesis of a trehazolamine diastereosiomeric analog with moderate α-mannosidase inhibitory activity has been developed starting from d-mannose and using a highly stereoselective ketone-oxime ether reductive carbocyclization promoted by samarium diiodide.

Peer reviewed

4 páginas.

Country

Spain

Related Organizations

Spanish National Research Council
Spain
Instituto de Química Orgánica General
Spain

Keywords

Samarium, Radical reactions, Carbohydrates, Carbocycles, Glycosidases

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