Highly reactive 4-membered ring nitrogen-containing heterocycles: Synthesis and properties.
Copyright policy )Highly reactive 4-membered ring nitrogen-containing heterocycles: Synthesis and properties.
4-Membered nitrogen-containing heterocycles, such as β-lactams (ie, 2-azetidinones) and azetidines, are useful substrates in organic chemistry for the design and preparation of biologically active compounds by functionalization of the different positions of the ring. In addition, these compounds are versatile building blocks for the synthesis of other types of nitrogen-containing compounds with potential biological properties. This review summarizes recent data regarding the preparation and properties of 4-membered nitrogen-containing heterocyclic rings, as well as their biological activities.
We would like to thank the Dirección General de Investigación-Ministerio de Ciencia e Innovación (DGI-MICINN) (Project CTQ2009-09318), Comunidad Autónoma de Madrid (CAM) (Project S2009/PPQ-1752) and Universidad Complutense-Banco Santander Central Hispano (UCM-BSCH) (Grant GR58/08) for financial support. C. A. thanks Ministerio de Ciencia e Innovación (MICINN) for a Ramón y Cajal contract co-financed by the European Social Fund.
13 páginas, 15 esquemas.-- El documento en word es el artículo post-print.
Peer reviewed
Rearrangements, Molecular Structure, Chemistry, Pharmaceutical, β-lactams, Drug Evaluation, Preclinical, Stereoselectivity, Heterocycles, beta-Lactams, Strain, Anti-Infective Agents, Heterocyclic Compounds, Drug Design, Animals, Azetidines
Rearrangements, Molecular Structure, Chemistry, Pharmaceutical, β-lactams, Drug Evaluation, Preclinical, Stereoselectivity, Heterocycles, beta-Lactams, Strain, Anti-Infective Agents, Heterocyclic Compounds, Drug Design, Animals, Azetidines
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