Importance of considering pesticide stereoisomerism––proposal of a scheme to apply Directive 91/414/EEC framework to pesticide active substances manufactured as isomeric mixtures

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2002 English Publisher:Elsevier BVJournal:Chemosphere, volume 49, pages 461-469 (issn: 0045-6535,

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Authors: Magrans, J. O.; Alonso-Prados, J. L.; García-Baudín, J. M.;

doi: 10.1016/s0045-6535(02)00314-4

pmid: 12363318

handle: 10261/291835

Importance of considering pesticide stereoisomerism––proposal of a scheme to apply Directive 91/414/EEC framework to pesticide active substances manufactured as isomeric mixtures

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Abstract

An important gap has been detected in the application of the European framework for the evaluation of pesticide active substances constituted by enantiomeric and other kind of stereoisomeric mixtures. Up to date, little attention has been paid to the different biological properties of these compounds. Considering efficacy, toxicity, environmental fate and behaviour and ecotoxicity of separated isomers is necessary to fulfil Directive 91/414/EEC objectives of health and environment protection. Here, a critical review of this question for pesticide active substances is presented. An evaluative scheme for considering this question in the framework of Directive 91/414/EEC is also proposed.

Related Organizations

Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
Spain

Keywords

Enantiomers, Stereoisomerism, European Union, Public Health, Pesticides, Active substance definition, Isomeric agrochemicals, Pesticide registration, Directive 91/414/EEC, Directive 94/37/EC

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