Nitrogen-containing compounds, particularly amines and their derivatives, are important intermediates for pharmaceuticals, and for many others interesting compounds. The alkylation of amines is a widely used organic reaction involving an amine and an alkylating reagent having a good leaving group. The most prominent processes to obtain this alkylation of amines with allylic alcohols normally use a transition metal as catalyst to activate the hydroxyl group, promoting a nucleophilic substitution. (Scheme 1. N-alkylation of anilines with allylic alcohols under mild reaction conditions). In this study, we have replaced the use of common organic solvents and metals as catalysts in the model reaction between anilines and allylic alcohols by greener and milder conditions, including room temperature (Scheme 1). This is an improvement over most examples reported in the literature, where higher temperatures and stronger reaction conditions are usually used. These features make our approach an attractive metal-free green alternative to develop this process.

Resumen del póster presentado a la XXXVIII Reunión Bienal de la Real Sociedad Española de Química, celebrada en el Palacio de Congresos de Granada, del 27 de junio al 30 de junio de 2022.

Peer reviewed