Downloads provided by UsageCountsAllelic Variation at the 8q23.3 Colorectal Cancer Risk Locus Functions as a Cis-Acting Regulator of EIF3H
Copyright policy ) Pittman, AM; Naranjo, S; Jalava, SE; Twiss, P; Ma, Y; Olver, B; Lloyd, A; Vijayakrishnan, J; Qureshi, M; Broderick, P; van Wezel, T; Morreau, H; Tuupanen, S; Aaltonen, LA; Alonso, ME; Manzanares, M; Gavilán, A; Visakorpi, T; Gómez-Skarmeta, JL; Houlston, RS;
Allelic Variation at the 8q23.3 Colorectal Cancer Risk Locus Functions as a Cis-Acting Regulator of EIF3H
Common genetic variation at human 8q23.3 is significantly associated with colorectal cancer (CRC) risk. To elucidate the basis of this association we compared the frequency of common variants at 8q23.3 in 1,964 CRC cases and 2,081 healthy controls. Reporter gene studies showed that the single nucleotide polymorphism rs16888589 acts as an allele-specific transcriptional repressor. Chromosome conformation capture (3C) analysis demonstrated that the genomic region harboring rs16888589 interacts with the promoter of gene for eukaryotic translation initiation factor 3, subunit H (EIF3H). We show that increased expression of EIF3H gene increases CRC growth and invasiveness thereby providing a biological mechanism for the 8q23.3 association. These data provide evidence for a functional basis for the non-coding risk variant rs16888589 at 8q23.3 and provides novel insight into the etiological basis of CRC.
Netherlands, Finland, United Kingdom
- Spanish National Research Council Spain
- University of Helsinki Finland
- University College London United Kingdom
- Tampere University Hospital Finland
- Institute of Cancer Research United Kingdom
Male, genome-wide association gene-expression profiles susceptibility loci prostate-cancer chromosome 8q24 rs6983267 variant scan predisposition transgenesis, Eukaryotic Initiation Factor-3, VARIANT, Electrophoretic Mobility Shift Assay, QH426-470, Regulatory Sequences, Nucleic Acid, Linkage Disequilibrium, Basic medicine, Risk Factors, Genes, Reporter, Tumor, Single Nucleotide, Middle Aged, PROSTATE-CANCER, Gene Expression Regulation, Neoplastic, Pair 8, Female, Colorectal Neoplasms, Human, Research Article, Chromosomes, Human, Pair 8, Protein Binding, SUSCEPTIBILITY LOCI, RS6983267, Polymorphism, Single Nucleotide, Chromosomes, Cell Line, Cell Line, Tumor, Genetics, Humans, Genetic Predisposition to Disease, Polymorphism, GENOME-WIDE ASSOCIATION, Reporter, CHROMOSOME 8Q24, Alleles, Cell Proliferation, Neoplastic, Nucleic Acid, Genetic Variation, TRANSGENESIS, PREDISPOSITION, Gene Expression Regulation, Genes, Genetic Loci, GENE-EXPRESSION PROFILES, Regulatory Sequences, SCAN
Male, genome-wide association gene-expression profiles susceptibility loci prostate-cancer chromosome 8q24 rs6983267 variant scan predisposition transgenesis, Eukaryotic Initiation Factor-3, VARIANT, Electrophoretic Mobility Shift Assay, QH426-470, Regulatory Sequences, Nucleic Acid, Linkage Disequilibrium, Basic medicine, Risk Factors, Genes, Reporter, Tumor, Single Nucleotide, Middle Aged, PROSTATE-CANCER, Gene Expression Regulation, Neoplastic, Pair 8, Female, Colorectal Neoplasms, Human, Research Article, Chromosomes, Human, Pair 8, Protein Binding, SUSCEPTIBILITY LOCI, RS6983267, Polymorphism, Single Nucleotide, Chromosomes, Cell Line, Cell Line, Tumor, Genetics, Humans, Genetic Predisposition to Disease, Polymorphism, GENOME-WIDE ASSOCIATION, Reporter, CHROMOSOME 8Q24, Alleles, Cell Proliferation, Neoplastic, Nucleic Acid, Genetic Variation, TRANSGENESIS, PREDISPOSITION, Gene Expression Regulation, Genes, Genetic Loci, GENE-EXPRESSION PROFILES, Regulatory Sequences, SCAN
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).74 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10% views 53 downloads 64 - 53views64downloads
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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