Interleukin‐6 (IL‐6) is a pleiotropic cytokine with complex and major roles in inflammation, which could be linked to the different ways IL‐6 signals at the plasma membrane. In this issue of FEBS Journal, Woo and co‐workers present evidence for the involvement of Eps15 homology domain‐containing protein 1 (EHD1)‐mediated lipid raft platforms, highly enriched in cholesterol, in the IL‐6 signalling pathway. Because of the strong connection between IL‐6, inflammation and cancer, one implication of this report is that agents or approaches targeting cholesterol‐rich raft platforms may assist the development of novel strategies to treat inflammatory and malignant diseases.Comment on: https://doi.org/10.1111/febs.16458