Synthesis of (R)- and (S)-2-amino-2-methylbutanoic acid (Iva) in enantiomerically pure form

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1993 English Publisher:Elsevier BVJournal:Tetrahedron: Asymmetry, volume 4, pages 1,445-1,448 (issn: 0957-4166,

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Authors: Cativiela, Carlos; Díaz de Villegas, María D.; Gálvez, José A.;

doi: 10.1016/s0957-4166(00)80337-7

handle: 10261/272767

Synthesis of (R)- and (S)-2-amino-2-methylbutanoic acid (Iva) in enantiomerically pure form

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Abstract

A new strategy for the preparation of both enantiomers of 2-amino-methylbutanoic acid (Iva) based on diastereoselective alkylation of (1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyanoesters and the corresponding degradation process is described.

This work was supported by the Dirección General de Investigación Científica y Técnica, project number PB91-0898.

Peer reviewed

Related Organizations

Spanish National Research Council
Spain
University of Zaragoza
Spain

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