Synthesis of (R)- 3-alkyl-3-benzyl-2-azetidinones in enantiomerically pure form

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1993 Spain English Publisher:Elsevier BVJournal:Tetrahedron: Asymmetry, volume 4, pages 229-238 (issn: 0957-4166,

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Authors: Cativiela, Carlos; Díaz de Villegas, María D.; Gálvez, José A.;

doi: 10.1016/s0957-4166(00)82343-5

handle: 10261/272765

Synthesis of (R)- 3-alkyl-3-benzyl-2-azetidinones in enantiomerically pure form

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Abstract

The diastereoselective alkylation of the enolate of 10-dicyclohexylsulfamoylisobornyl 3-phenyl-2-cyanopropanoate is reported. This alkylation took place with very good yield and selectivity and the reaction product was reduced and cyclised to the corresponding β-lactam in high yield.

This work was supported by the Dirección General de Investigación Científica y Técnica, project number PB91-0898.

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Country

Spain

Related Organizations

Spanish National Research Council
Spain
University of Zaragoza
Spain

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