Asymmetric synthesis of 3,3-diphenyl-2-methylalanine, a new unusual α-amino acid for peptides of biological interest

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1994 English Publisher:Elsevier BVJournal:Tetrahedron, volume 50, pages 9,837-9,846 (issn: 0040-4020,

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Authors: Cativiela, Carlos; Díaz de Villegas, María D.; Gálvez, José A.;

doi: 10.1016/s0040-4020(01)85549-6

handle: 10261/271102

Asymmetric synthesis of 3,3-diphenyl-2-methylalanine, a new unusual α-amino acid for peptides of biological interest

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Abstract

A strategy of highly stereoselective enolate trapping of lithium (1S,2R,4R)- 10-dicyclohexylsulfamoylisobornyl-2-cyano-3,3-diphenylpropanoate combined with the appropriate rearrangement process allows the asymmetric synthesis of a novel a-methyl amino acid derived from 3,3diienylalanine (Dip). This work was supported by the Direccion General de Investigacion Cientifica y Tecnica, project number P691-0696. Peer reviewed

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Spanish National Research Council
Spain

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