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Evidence from theories of Developmental Origins of Health and Disease (DOHaD) suggests that experiencing adverse early life conditions subsequently leads to detrimental adult health outcomes. The bulk of empirical DOHaD literature does not consider the nature and magnitude of the impact of adverse early life conditions at the population level. In particular, it ignores the distortion of age and cohort patterns of adult health and mortality and the increased load of chronic illness and disability that ensues. In this paper, we use a microsimulation model combined with empirical estimates of incidence and prevalence of obesity, type 2 diabetes, and associated disability in low- and middle-income countries to assess the magnitude of delayed effects on adult healthy life expectancy and on compression (or expansion) of morbidity at older ages. The main goal is to determine if, in what ways, and to what extent delayed effects due to early conditions can influence cohorts' chronic illness and disability profiles.
Adult, senescence, 330, compression of morbidity, morbidity, Delayed effects, 613, Senescence, Life Expectancy, Diabetes Mellitus, Humans, Compression of morbidity, Developing Countries, Healthy Life Expectancy, healthy life expectancy, Healthy life expectancy, Older-age mortality patterns, Diabetes Mellitus, Type 2, Chronic Disease, delayed effects, Morbidity, Type 2, older-age mortality patterns
Adult, senescence, 330, compression of morbidity, morbidity, Delayed effects, 613, Senescence, Life Expectancy, Diabetes Mellitus, Humans, Compression of morbidity, Developing Countries, Healthy Life Expectancy, healthy life expectancy, Healthy life expectancy, Older-age mortality patterns, Diabetes Mellitus, Type 2, Chronic Disease, delayed effects, Morbidity, Type 2, older-age mortality patterns
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 7 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 10% | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |
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