Prosthetic Shoulder Joint Infection by Cutibacterium acnes: Does Rifampin Improve Prognosis? A Retrospective, Multicenter, Observational Study

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 21 Apr 2021 Spain English Publisher:MDPI AGJournal:Antibiotics, volume 10, page 475 (eissn: 2079-6382,

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Authors: Helem H, Vilchez; Rosa, Escudero-Sanchez; Marta, Fernandez-Sampedro; Oscar, Murillo; Álvaro, Auñón; Dolors, Rodríguez-Pardo; Alfredo, Jover-Sáenz; +13 Authors

doi: 10.3390/antibiotics10050475

pmid: 33919103

pmc: PMC8143127

handle: 11441/125813 , 2445/189350 , 10261/261474 , 20.500.12530/59687 , 10668/17675 , 11351/6706

Prosthetic Shoulder Joint Infection by Cutibacterium acnes: Does Rifampin Improve Prognosis? A Retrospective, Multicenter, Observational Study

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Abstract

This retrospective, multicenter observational study aimed to describe the outcomes of surgical and medical treatment of C. acnes-related prosthetic joint infection (PJI) and the potential benefit of rifampin-based therapies. Patients with C. acnes-related PJI who were diagnosed and treated between January 2003 and December 2016 were included. We analyzed 44 patients with C. acnes-related PJI (median age, 67.5 years (IQR, 57.3–75.8)); 75% were men. The majority (61.4%) had late chronic infection according to the Tsukayama classification. All patients received surgical treatment, and most antibiotic regimens (43.2%) included β-lactam. Thirty-four patients (87.17%) were cured; five showed relapse. The final outcome (cure vs. relapse) showed a nonsignificant trend toward higher failure frequency among patients with previous prosthesis (OR: 6.89; 95% CI: 0.80–58.90) or prior surgery and infection (OR: 10.67; 95% IC: 1.08–105.28) in the same joint. Patients treated with clindamycin alone had a higher recurrence rate (40.0% vs. 8.8%). Rifampin treatment did not decrease recurrence in patients treated with β-lactams. Prior prosthesis, surgery, or infection in the same joint might be related to recurrence, and rifampin-based combinations do not seem to improve prognosis. Debridement and implant retention appear a safe option for surgical treatment of early PJI.

Country

Spain

Related Organizations

Autonomous University of Barcelona
Spain
University of Seville
Spain
Hospital Clinic of Barcelona
Spain
Vall d'Hebron Hospital Universitari
Spain
Osakidetza
Spain

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Keywords

Prosthetic joint infection, Lactams, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, Terapéutica, ENFERMEDADES::infecciones bacterianas y micosis::infección::infecciones relacionadas con prótesis, Recurrencia, DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections, Prosthesis, RM1-950, Clasificación, Infections, surgical and medical treatment, Article, Surgical and medical treatment, Clindamicina, Recurrence, Acne Vulgaris, <i>Cutibacterium acnes</i>, Malalties bacterianes - Tractament, Medicaments antibacterians - Ús terapèutic, Pròtesis, Desbridamiento, prosthetic joint infection, Other subheadings::Other subheadings::Other subheadings::/drug therapy, DISEASES::Bacterial Infections and Mycoses::Infection::Prosthesis-Related Infections, Cirurgia, Clindamycin, Bacteris anaerobis, Articulacions artificials, Prostheses and Implants, Lactamas, Prognosis, Infeccions, Anti-Bacterial Agents, Anaerobic bacteria, Articulaciones, Debridement, Antibacterianos, CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents, ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas, COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antibacterianos, Female, Surgery, Therapeutics. Pharmacology, Cutibacterium acnes, Rifampin

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