Genetic Insights Into Biological Mechanisms Governing Human Ovarian Ageing

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 04 Aug 2021Embargo end date: 02 Jun 2021 United States, Netherlands, Italy, United Kingdom, Netherlands, Croatia, United Kingdom, Germany, Spain, United States, Italy, France, Australia, Denmark, Netherlands, Italy, Italy, Australia, Netherlands, Italy, United Kingdom, Germany, United Kingdom, Netherlands, United Kingdom, United Kingdom, United Kingdom English Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:Obstetrical & Gynecological Survey, volume 76, pages 678-679 (issn: 0029-7828, eissn: 1533-9866,

Copyright policy )Funded by:EC | ReCAP, EC | CFS modelling

Authors: Ruth, Katherine S; Day, Felix R; Hussain, Jazib; Martínez-Marchal, Ana; Aiken, Catherine E; Azad, Ajuna; Thompson, Deborah J; +193 Authors

Ruth, Katherine S; Day, Felix R; Hussain, Jazib; Martínez-Marchal, Ana; Aiken, Catherine E; Azad, Ajuna; Thompson, Deborah J; Knoblochova, Lucie; Abe, Hironori; Tarry-Adkins, Jane L; Gonzalez, Javier Martin; Fontanillas, Pierre; Claringbould, Annique; Bakker, Olivier B; Sulem, Patrick; Walters, Robin G; Terao, Chikashi; Turon, Sandra; Horikoshi, Momoko; Lin, Kuang; Onland-Moret, N Charlotte; Sankar, Aditya; Hertz, Emil Peter Thrane; Timshel, Pascal N; Shukla, Vallari; Borup, Rehannah; Olsen, Kristina W; Aguilera, Paula; Ferrer-Roda, Mònica; Huang, Yan; Stankovic, Stasa; Timmers, Paul RHJ; Ahearn, Thomas U; Alizadeh, Behrooz Z; Naderi, Elnaz; Andrulis, Irene L; Arnold, Alice M; Aronson, Kristan J; Augustinsson, Annelie; Bandinelli, Stefania; Barbieri, Caterina M; Beaumont, Robin N; Becher, Heiko; Beckmann, Matthias W; Benonisdottir, Stefania; Bergmann, Sven; Bochud, Murielle; Boerwinkle, Eric; Bojesen, Stig E; Bolla, Manjeet K; Boomsma, Dorret I; Bowker, Nicholas; Brody, Jennifer A; Broer, Linda; Buring, Julie E; Campbell, Archie; Campbell, Harry; Castelao, Jose E; Catamo, Eulalia; Chanock, Stephen J; Chenevix-Trench, Georgia; Ciullo, Marina; Corre, Tanguy; Couch, Fergus J; Cox, Angela; Crisponi, Laura; Cross, Simon S; Cucca, Francesco; Czene, Kamila; Smith, George Davey; de Geus, Eco JCN; de Mutsert, Renée; De Vivo, Immaculata; Demerath, Ellen W; Dennis, Joe; Dunning, Alison M; Dwek, Miriam; Eriksson, Mikael; Esko, Tõnu; Fasching, Peter A; Faul, Jessica D; Ferrucci, Luigi; Franceschini, Nora; Frayling, Timothy M; Gago-Dominguez, Manuela; Mezzavilla, Massimo; García-Closas, Montserrat; Gieger, Christian; Giles, Graham G; Grallert, Harald; Gudbjartsson, Daniel F; Gudnason, Vilmundur; Guénel, Pascal; Haiman, Christopher A; Håkansson, Niclas; Hall, Per; Hayward, Caroline; He, Chunyan; He, Wei; Heiss, Gerardo; Høffding, Miya K; Hopper, John L; Hottenga, Jouke J; Hu, Frank; Hunter, David; Ikram, Mohammad A; Jackson, Rebecca D; Joaquim, Micaella DR; John, Esther M; Joshi, Peter K; Karasik, David; Kardia, Sharon LR; Kartsonaki, Christiana; Karlsson, Robert; Kitahara, Cari M; Kolcic, Ivana; Kooperberg, Charles; Kraft, Peter; Kurian, Allison W; Kutalik, Zoltan; La Bianca, Martina; LaChance, Genevieve; Langenberg, Claudia; Launer, Lenore J; Laven, Joop SE; Lawlor, Deborah A; Le Marchand, Loic; Li, Jingmei; Lindblom, Annika; Lindstrom, Sara; Lindstrom, Tricia; Linet, Martha; Liu, YongMei; Liu, Simin; Luan, Jian'an; Mägi, Reedik; Magnusson, Patrik KE; Mangino, Massimo; Mannermaa, Arto; Marco, Brumat; Marten, Jonathan; Martin, Nicholas G; Mbarek, Hamdi; McKnight, Barbara; Medland, Sarah E; Meisinger, Christa; Meitinger, Thomas; Menni, Cristina; Metspalu, Andres; Milani, Lili; Milne, Roger L; Montgomery, Grant W; Mook-Kanamori, Dennis O; Mulas, Antonella; Mulligan, Anna M; Murray, Alison; Nalls, Mike A; Newman, Anne; Noordam, Raymond; Nutile, Teresa; Nyholt, Dale R; Olshan, Andrew F; Olsson, Håkan; Painter, Jodie N; Patel, Alpa V; Pedersen, Nancy L; Perjakova, Natalia; Peters, Annette; Peters, Ulrike; Pharoah, Paul DP; Polasek, Ozren; Porcu, Eleonora; Psaty, Bruce M; Rahman, Iffat; Rennert, Gad; Rennert, Hedy S; Ridker, Paul M; Ring, Susan M; Robino, Antonietta; Rose, Lynda M; Rosendaal, Frits R; Rossouw, Jacques; Rudan, Igor; Rueedi, Rico; Ruggiero, Daniela; Sala, Cinzia F; Saloustros, Emmanouil; Sandler, Dale P; Sanna, Serena; Sawyer, Elinor J; Sarnowski, Chloé; Schlessinger, David; Schmidt, Marjanka K; Schoemaker, Minouk J; Schraut, Katharina E; Scott, Christopher; Shekari, Saleh; Shrikhande, Amruta; Smith, Albert V; Smith, Blair H;

doi: 10.1097/01.ogx.0000800176.90737.65 , 10.1038/s41586-021-03779-7 , 10.17615/9a86-3a84 , 10.17863/cam.70746

pmid: 34349265

pmc: PMC7611832

handle: 10261/259185 , 1871.1/6184818a-66a7-4f65-9505-980861655a5c , 11370/9fbd6e42-cbd0-4c2d-a81b-b849aea4924e , 1887/3217417 , 20.500.14243/403023 , 2434/1095634 , 11388/346529 , 10668/18292 , 1983/784cb6a1-dcfe-45d5-a9e7-3dc68275d2d2 , 20.500.11820/994616ef-711a-4b8f-abd8-8ab05c64a7bc , 11577/3455576 , 11343/309729 , 10871/126956

Genetic Insights Into Biological Mechanisms Governing Human Ovarian Ageing

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Abstract

(Abstracted from Nature 2021;596:393–397) The age of reproductive senescence (age of natural menopause [ANM]) in developed countries is approximately 50–52 years; however, natural fertility ceases approximately 10 years before menopause. Societal trends have shifted with women choosing to delay childbearing to older ages, increasing the need for assisted conception technology.

Countries

United States, Netherlands, Italy, United Kingdom, Netherlands, Croatia, United Kingdom, Germany, Spain, United States, Italy, France, Australia, Denmark, Netherlands, Italy, Italy, Australia, Netherlands, Italy, United Kingdom, Germany, United Kingdom, Netherlands, United Kingdom, United Kingdom, United Kingdom

Related Organizations

Technion – Israel Institute of Technology
Israel
University of Michigan–Flint
United States
University Medical Center Groningen
Netherlands
University of Southern California
United States
Boston University
United States

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Keywords

Aging, Checkpoint Kinase 2/genetics, Eastern, VARIANTS, Primary Ovarian Insufficiency, DISEASE, /dk/atira/pure/core/keywords/icep, Mice, EARLY MENOPAUSE, Asia, Eastern, Longevity/genetics, Biobank-based Integrative Omics Study (BIOS) Consortium, General Medicine, Healthy Aging/genetics, [SDV] Life Sciences [q-bio], Type 2, Adult; Aging; Alleles; Animals; Bone and Bones; Checkpoint Kinase 1; Checkpoint Kinase 2; Diabetes Mellitus, Type 2; Diet; Europe; Far East; Female; Fertility; Fragile X Mental Retardation Protein; Genetic Predisposition to Disease; Genome-Wide Association Study; Healthy Aging; Humans; Longevity; Menopause; Menopause, Premature; Mice; Mice, Inbred C57BL; Middle Aged; Ovary; Primary Ovarian Insufficiency; Uterus, 570, 1.1 Normal biological development and functioning, Longevity, Reproductive biology, 610, Bone and Bones, 618, genome-wide meta-analysis, SDG 3 - Good Health and Well-being, Premature/genetics, Genetics, Diabetes Mellitus, Humans, Premature, China Kadoorie Biobank Collaborative Group, Alleles, Checkpoint Kinase 1/genetics, Prevention, CHROMOSOME SYNAPSIS, Mice, Inbred C57BL, Ageing, Checkpoint Kinase 2, Diabetes Mellitus, Type 2, Checkpoint Kinase 1, Fragile X Mental Retardation Protein/genetics, LifeLines Cohort Study, MEIOTIC CELL-CYCLE, MEIOTIC CELL-CYCLE ; DNA-DAMAGE ; MENDELIAN RANDOMIZATION ; CHROMOSOME SYNAPSIS ; EXPRESSION ANALYSIS ; EARLY MENOPAUSE ; GERMLINE ; VARIANTS ; DISEASE ; RISK, [SDV]Life Sciences [q-bio], Menopause, Premature, Menopause/genetics, Inbred C57BL, Genome-wide association studies, Healthy Aging, Fragile X Mental Retardation Protein, genetics of ovarian aging, Biobank Japan Project, Aging/genetics, 2.1 Biological and endogenous factors, eQTLGen Consortium, RISK, Ovary/metabolism, Far East/ethnology, Obstetrics and Gynecology, Biological Sciences, Middle Aged, Europe, MENDELIAN RANDOMIZATION, kConFab Investigators, Female, Menopause, Endocrine reproductive disorders, Adult, Asia, General Science & Technology, Bone and Bones/metabolism, 23andMe Research Team, Europe/ethnology, GERMLINE, Animals, Genetic Predisposition to Disease, /dk/atira/pure/core/keywords/icep; name=ICEP, Fragile X Messenger Ribonucleoprotein 1, Biomedical and Clinical Sciences, name=ICEP, Contraception/Reproduction, Ovary, Uterus, Primary Ovarian Insufficiency/genetics, Estrogen, Diet, Good Health and Well Being, Fertility, DNA-DAMAGE, Infertility, InterAct consortium, Fertility/genetics, Women's Health, EXPRESSION ANALYSIS, Genome-Wide Association Study

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