[EN]: Long-chain fatty acids (LCFAs) contribute to many cellular functions including energy homeostasis and activation of nuclear transcription factors. However, to perform their diverse effects, LCFAs have first to traverse the plasma membrane, a process that can occur either through diffusion or be mediated by proteins. Fatty acid transport proteins (FATPs solute carrier family 27) are integral transmembrane proteins that enhance the uptake of long-chain fatty acids into cells. Although in humans six highly homologous FATPs proteins are found in practically all tissues, in the porcine species that information is limited. With the aim to increase the knowledge of these genes in pigs, different approaches have been followed. First, three partial fragments of FATP1 and FATP4 genes have been amplified and sequenced. Subsequently, we have used the clustalw software to identified polymorphisms in the porcine sequence. And finally, a preliminary association study was conducted identifying a polymorphism (FATP1c.491C>T) of FATP1 gene with significant effects in the relative distribution of stearic and saturated fatty acid levels in longissimus dorsi and gluteus medius muscles.

Este trabajo ha sido financiado mediante el proyecto Mapeo e identificación de genes implicados en el metabolismo lipídico en porcino, la calidad de la carne y la calidad del jamón curado (AGL2007-66707-C02-02).

Trabajo presentado a las XIII Jornadas sobre producción animal, celebradas en Zaragoza del 12 al 13 de Mayo de 2009.

Peer reviewed