Aripiprazole and olanzapine are atypical antipsychotics. Both drugs can induce metabolic and cardiovascular changes and adverse drug reactions. Pupillography is a non-invasive and costeffective method to determine autonomic nerve activity during antipsychotic treatment. The aims of the study were to optimize and validate a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to measure drug concentrations; to evaluate the effects of aripiprazole and olanzapine on pupillary light reflex; prolactin levels, lipid and glucose metabolism; hepatic, hematological, thyroid and renal performance; adverse events and safety and to assess the relationship between these parameters and pharmacogenetics. Genetic variants in cytochrome P450 (CYP), dopamine receptor (DRD2, DRD3), serotonin receptor (HTR2A, HTR2C) and ATPbinding cassette subfamily B (ABCB1) genes, among others, may be associated with the pharmacokinetics and pharmacodynamics of antipsychotic drugs.

This work was supported by the following grant: Horizon 2020 Marie Sklodowska-Curie Innovative Training Network 721236 grant to Dóra Koller and Francisco Abad-Santos.

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Farmacología. Fecha de lectura: 23-07-2020

Peer reviewed