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Procedimiento de obtención de glicoconjugados

Authors: Nieto-Domínguez, Manuel José; Martínez, María Jesús; Cañada, F. Javier; Santana, Andrés G.; Prieto Orzanco, Alicia; Asensio, Juan Luis;

Procedimiento de obtención de glicoconjugados

Abstract

La presente invención es un procedimiento de obtención de un glicoconjugado, que comprende poner en presencia de una tioglicoligasa de la familia GH3 una molécula de carbohidrato unida a un buen grupo saliente como donador, y una molécula orgánica con un grupo funcional en su forma neutra como aceptor, a un valor de pH próximo al valor de pKa del mencionado grupo funcional, con la condición de que dicho aceptor no presente en su estructura una carga positiva o negativa capaz de interaccionar con dicho centro activo. La tioglicoligasa obtenida aumenta sorprendentemente la gama de aceptores válidos para formar glicoconjugados.

A1 Solicitud de patente con informe sobre el estado de la técnica

Consejo Superior de Investigaciones Científicas (España)

Peer reviewed

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
downloads
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105
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