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handle: 10261/242277
Rhoq como diana farmacéutica para trastornos neurológicos. La invención hace referencia al uso del gen Rhoq como diana farmacológica para el cribado, ensayo, y/o validación de moléculas, compuestos, agentes, y moduladores útiles en el tratamiento y/o prevención de enfermedades neurológicas, preferiblemente enfermedades neurodegenerativas. Más preferiblemente, la invención hace referencia también a moléculas, compuestos, agentes, y moduladores capaces de inhibir la expresión del gen Rhoq, induciendo un fenotipo neuroprotector de células microgliales lo que posibilita reducir o detener los procesos de neurodegeneración que ocurren mamíferos, preferiblemente humanos.
A1 Solicitud de patente con informe sobre el estado de la técnica
Consejo Superior de Investigaciones Científicas (España)
Peer reviewed
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