Utilisation of rapeseed protein isolates for production of peptides with angiotensin I-converting enzyme (ACE)-inhibitory activity

descriptionPublicationkeyboard_double_arrow_right Article 30 Dec 2004Publisher:Editorial CSICJournal:Grasas y Aceites, volume 55, pages 354-358 (issn: 0017-3495, eissn: 1988-4214,

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Authors: Justo Pedroche; María M. Yust; Cristina Megías; Hassane Lqari; Manuel Alaiz; Julio Girón-Calle; Francisco Millán; +1 Authors

doi: 10.3989/gya.2004.v55.i4.200

handle: 10261/2421

Utilisation of rapeseed protein isolates for production of peptides with angiotensin I-converting enzyme (ACE)-inhibitory activity

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Abstract

ACE activity is related to increased arterial pressure and coronary diseases. A rapeseed protein isolate was hydrolyzed with the protease Alcalase in order to investigate the possible presence of ACE inhibitory peptides in the resulting hydrolysates. Hydrolysis for 30 min yielded a hydrolysate with the highest ACE inhibitory activity. Two fractions of this hydrolysate obtained by Biogel P2 gel filtration chromatography were used for further purification of ACE inhibitory peptides. Three fractions with ACE inhibitory activity were purified by reverse-phase HPLC of Biogel P2 f ractions. This demonstrates that rapeseed protein hydrolysates represent a good source of ACE inhibitory peptides .

Related Organizations

Spanish National Research Council
Spain

Keywords

Aislado proteico, Nutrition. Foods and food supply, protein isolate, rapeseed, peptide inhibitors, Protein hydrolysate, Colza, Peptide inhibitors, Rapeseed, Protein isolate, Péptidos inhibidores, Enzima convertidora de angiotensina, TX341-641, Angiotensin converting enzyme, Hidrolizado proteico, angiotensin converting enzyme, protein hydrolysate

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