A Bifunctional Metal/Acid Catalyst for One-pot Multistep Synthesis of Pharmaceuticals

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2020 English Publisher:Pleiades Publishing LtdJournal:Petroleum Chemistry, volume 60, pages 499-507 (issn: 0965-5441, eissn: 1555-6239,

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Authors: López Prado, Mª Victoria; Sabater Picot, Mª José; Corma Canós, Avelino|||0000-0002-2232-3527;

doi: 10.1134/s0965544120040106

handle: 10261/233157

A Bifunctional Metal/Acid Catalyst for One-pot Multistep Synthesis of Pharmaceuticals

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Abstract

One inhibitor of the fatty acid transporter FATP4 was synthesized in a three steps one-pot process in the presence of a bifunctional metal/acid catalyst. This molecule which has potential interest for the treatment of the obesity in orlistat (Xenical TM) analogue-based therapies has a 3,4-dihydropyrimidin-2(1H)-one (DHPM) scaffold and was obtained by means of a three one-pot process through successive oxidation, cyclocondensation and transesterification reactions. The one-pot strategy was extended to the synthesis of a series of related ester DHPM derivatives.

Financial support by the Ministerio de Economia y Competitividad, Programa Severo Ochoa (SEV2016-0683) and Ministerio de Ciencia Innovacion y Universidades, Programa Estatal de Generación de Conocimiento (PGC2018-101247-B-100) are gratefully acknowledged.

Related Organizations

Universitat Politècnica de València
Spain
Instituto de Tecnología Química
Spain
Spanish National Research Council
Spain

Keywords

Dihydropyrimidinone, QUIMICA ORGANICA, Pharmaceuticals, One-pot, synthesis, Catalyst, Bifunctional

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