Downloads provided by UsageCountsDiscovery of Homobivalent Bitopic Ligands Of The Cannabinoid Cb2 Receptor
Copyright policy ) Paula Morales; Gemma Navarro; Marc Gómez‐Autet; Laura Redondo; Javier Fernández‐Ruiz; Laura Pérez‐Benito; Arnau Cordomí; +3 Authors
Paula Morales; Gemma Navarro; Marc Gómez‐Autet; Laura Redondo; Javier Fernández‐Ruiz; Laura Pérez‐Benito; Arnau Cordomí; Leonardo Pardo; Rafael Franco; Nadine Jagerovic;
Discovery of Homobivalent Bitopic Ligands Of The Cannabinoid Cb2 Receptor
Abstract Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB 2 receptor. These compounds selectively target CB 2 versus CB 1 receptors. Their binding mode was studied by molecular dynamic simulations and site‐directed mutagenesis.
Spain
Proteïnes G, Molecular dynamics, Molecular Dynamics Simulation, Ligands, Receptor, Cannabinoid, CB2, GPCR, G protein-coupled receptors, Cànnabis, Cell receptors, Cannabis, Site-directed mutagenesis, Interacció cel·lular, Binding Sites, CB2 cannabinoid, molecular dynamics, Communications, Bitopic ligand, Cell interaction, Mutagenesis, Site-Directed, bitopic ligands, Receptors cel·lulars, G Proteins, site-directed mutagenesis
Proteïnes G, Molecular dynamics, Molecular Dynamics Simulation, Ligands, Receptor, Cannabinoid, CB2, GPCR, G protein-coupled receptors, Cànnabis, Cell receptors, Cannabis, Site-directed mutagenesis, Interacció cel·lular, Binding Sites, CB2 cannabinoid, molecular dynamics, Communications, Bitopic ligand, Cell interaction, Mutagenesis, Site-Directed, bitopic ligands, Receptors cel·lulars, G Proteins, site-directed mutagenesis
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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