Volumetric and morphological hippocampal abnormalities are one of the key features of psychotic disorders. Architectural alterations in hippocampal pyramidal neurons have been observed post-mortem in schizophrenia, mainly due to decreased dendritic arborisation and spine density. The in vivo study of grey-matter texture features, which might be sensitive to microstructural abnormalities, may further contribute to the characterisation of hippocampal pathology. However, these characterization techniques have been hardly used in psychiatry. We therefore propose the use of radiomics, able to capture both shape and texture characteristics, for hippocampal characterization in first episode psychosis when compared with healthy volunteers. We evaluated the use of classical statistics and machine learning approaches for differential pattern recognition.

Resumen del trabajo presentado en el Congress of the Schizophrenia International Research Socieaty (SIRS), celebrado del 4 al 8 de abril de 2020

Peer reviewed