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Importancia de la genómica en aves para entender su interacción con patógenos

Authors: García-Longoria, Luz; Ruiz-López, María José;

Importancia de la genómica en aves para entender su interacción con patógenos

Abstract

[ES] Una de las consecuencias de la acción humana y el cambio global es el aumento de enfermedades infecciosas no solo en humanos sino también en fauna silvestre. Los efectos negativos de los patógenos pueden ser devastadores llegando a diezmar poblaciones naturales e incluso causar la extinción de especies. Por ello, es imperativo un conocimiento más profundo de los mecanismos y estrategias que estos agentes llevan a cabo durante su ciclo de vida, así como las respuestas inmunológicas y bioquímicas que sus hospedadores naturales muestran durante la interacción hospedador- patógeno. Gracias al desarrollo de metodologías moleculares como la genómica y a través del análisis de transcriptomas hoy en día sabemos un poco más acerca de las cascadas bioquímicas y respuestas inmunológicas que se dan en la interacción hospedador-patógeno. El presente artículo se centra en mostrar los avances en el estudio genómico y transcriptómico de infecciones en aves provocadas por parásitos del género Plasmodium y del Virus del Nilo Occidental. Así mismo, revisamos los problemas a los que los científicos deben hacer frente para un mejor entendimiento de la dinámica hospedador-patógeno

[ENG] Anthropogenic pressure and global change are favouring the increase of infectious diseases not only in humans but also in wildlife. The negative effects of pathogens can be devastating, affecting natural populations and even causing the extinction of species. Therefore, it is fundamental to understand the mechanisms and strategies that these agents develop during their life cycle, as well as the immunological and biochemical responses that natural hosts show during host-pathogen interaction. Development of new molecular tools such as genomics or the analysis of transcriptomes have provided the scientific community significant information about host-pathogen interactions, including the biochemical cascades and immunological responses that occur. This article focuses on showing the advances in this field in birds infected with avian Plasmodium and West Nile Virus. In addition, we also review the problems that scientists must face in order to better understand the host-pathogen dynamics

Peer reviewed

Keywords

Birds, Genomic, Pathogens, West Nile virus, Malaria

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green