Tryptophan Trimers and Tetramers Inhibit Dengue and Zika Virus Replication by Interfering with Viral Attachment Processes

descriptionPublicationkeyboard_double_arrow_right Article 21 Feb 2020 Belgium English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 64 (issn: 0066-4804, eissn: 1098-6596,

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Authors: Fikatas, Antonios; Vervaeke, Peter; Martinez-Gualda, Belen; Marti-Mari, Olaia; Noppen, Sam; Meyen, Eef; Camarasa, Maria-Jose; +3 Authors

doi: 10.1128/aac.02130-19

pmid: 31932383

pmc: PMC7038274

handle: 10261/219726

Tryptophan Trimers and Tetramers Inhibit Dengue and Zika Virus Replication by Interfering with Viral Attachment Processes

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Abstract

Here, we report a class of tryptophan trimers and tetramers that inhibit (at low micromolar range) dengue and Zika virus infection in vitro . These compounds (AL family) have three or four peripheral tryptophan moieties directly linked to a central scaffold through their amino groups; thus, their carboxylic acid groups are free and exposed to the periphery.

Country

Belgium

Related Organizations

KU Leuven
Belgium
Spanish National Research Council
Spain
Instituto de Química Médica
Spain
Rega Institute for Medical Research
Belgium

Keywords

MECHANISM, SPR, Zika, antivirals, dengue, envelope protein, virus attachme, TRANSMISSION, 3214 Pharmacology and pharmaceutical sciences, SPR, Serogroup, Virus Replication, Microbiology, SEQUENCE, Antiviral Agents, DISEASE, Structure-Activity Relationship, Zika, antivirals, Viral Envelope Proteins, DOMAIN-III, 1108 Medical Microbiology, HISTORY, Chlorocebus aethiops, Human Umbilical Vein Endothelial Cells, Animals, Humans, DENDRIMERS, Pharmacology & Pharmacy, Vero Cells, TYPE-1, Science & Technology, POTENT, Tryptophan, HIV, Zika Virus, Dengue Virus, dengue, 3207 Medical microbiology, envelope protein, 3107 Microbiology, HUMAN-IMMUNODEFICIENCY-VIRUS, 1115 Pharmacology and Pharmaceutical Sciences, Life Sciences & Biomedicine, virus attachment, 0605 Microbiology

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