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Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as “Hotspot-Targeted” Dimerization Inhibitors

descriptionPublicationkeyboard_double_arrow_right Article 24 Jan 2020 Italy, Spain English Publisher:American Chemical Society (ACS)Journal:ACS Medicinal Chemistry Letters, volume 11, pages 811-817 (issn: 1948-5875, eissn: 1948-5875, Copyright policy )
Authors: Pedro A. Sánchez-Murcia; Sonia de Castro; Carlos García-Aparicio; M. Angeles Jiménez; Angela Corona; Enzo Tramontano; Nicolas Sluis-Cremer; +4 Authors

doi: 10.1021/acsmedchemlett.9b00623

pmid: 32435389

pmc: PMC7236230

handle: 10261/218990 , 11584/283380

Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as “Hotspot-Targeted” Dimerization Inhibitors

Abstract

A conformationally constrained short peptide designed to target a protein-protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization inhibitors.

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Keywords

Dimerization hotspot, Constrained peptides, Dimerization inhibitors, Peptides; Hot spot mimics; Dimerization inhibitors; HIV-1 RT inhibitors, HIV reverse transcriptase.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
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11
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52
77
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