Impact of antibiotic resistance on outcomes of neutropenic cancer patients with  Pseudomonas aeruginosa  bacteraemia (IRONIC study): study protocol of a retrospective multicentre international study

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2019 Italy, Spain, Spain, Germany, Turkey, Turkey, Spain English Publisher:BMJJournal:BMJ Open, volume 9, page e025744 (issn: 2044-6055, eissn: 2044-6055,

Copyright policy )

Authors: Albasanz-Puig A; Gudiol C; Parody R; Tebe C; Akova M; Araos R; Bote A; +77 Authors

doi: 10.1136/bmjopen-2018-025744

pmid: 31129580

pmc: PMC6538198

handle: 10230/42865 , 20.500.12530/60752 , 2445/174887 , 10261/212446 , 11351/4254 , 10668/14022 , 11383/2129620 , 11567/957919 , 11454/29008

Impact of antibiotic resistance on outcomes of neutropenic cancer patients with Pseudomonas aeruginosa bacteraemia (IRONIC study): study protocol of a retrospective multicentre international study

- Summary
- Subjects
- Metrics

Abstract

Introduction Pseudomonas aeruginosa (PA) has historically been one of the major causes of severe sepsis and death among neutropenic cancer patients. There has been a recent increase of multidrug-resistant PA (MDRPA) isolates that may determine a worse prognosis, particularly in immunosuppressed patients. The aim of this study is to establish the impact of antibiotic resistance on the outcome of neutropenic onco-haematological patients with PA bacteraemia, and to identify the risk factors for MDRPA bacteraemia and mortality. Methods and analysis This is a retrospective, observational, multicentre, international study. All episodes of PA bacteraemia occurring in neutropenic onco-haematological patients followed up at the participating centres from 1 January 2006 to 31 May 2018 will be retrospectively reviewed. The primary end point will be overall case-fatality rate within 30 days of onset of PA bacteraemia. The secondary end points will be to describe the following: the incidence and risk factors for multidrug-resistant and extremely drug-resistant PA bacteraemia (by comparing the episodes due to susceptible PA with those produced by MDRPA), the efficacy of ceftolozane/tazobactam, the rates of persistent bacteraemia and bacteraemia relapse and the risk factors for very early (48 hours), early (7 days) and overall (30 days) case-fatality rates. Ethics and dissemination The Clinical Research Ethics Committee of Bellvitge University Hospital approved the protocol of the study at the primary site. To protect personal privacy, identifying information of each patient in the electronic database will be encrypted. The processing of the patients’ personal data collected in the study will comply with the Spanish Data Protection Act of 1998 and with the European Directive on the privacy of data. All data collected, stored and processed will be anonymised. Results will be reported at conferences and in peer-reviewed publications.

Countries

Italy, Spain, Spain, Germany, Turkey, Turkey, Spain

Related Organizations

Oswaldo Cruz Foundation
Brazil
Ege University
Turkey
Hospital Erasto Gaertner
Brazil
University of Genoa
Italy
Autonomous University of Barcelona
Spain

View all View all

Keywords

bacteraemia, Time Factors, International Cooperation, Bacteremia, bacteraemia; bloodstream infection; multidrug-resistant; neutropenia; onco-haematological patients; pseudomonas aeruginosa, pseudomonas aeruginosa, Bacterièmia, ORGANISMOS::Bacteria::bacterias gramnegativas::bacterias aerobias gramnegativas::bacilos y cocos aerobios gramnegativos::Pseudomonadaceae::Pseudomonas::Pseudomonas aeruginosa, Drug Resistance, Multiple, Bacterial, Neoplasms, Onco-haematological patients, Multicenter Studies as Topic, Multidrug-resistant, Microorganismes - Resistència als medicaments, Neutropènia, bacteraemia, bloodstream infection, multidrug-resistant, neutropenia, onco-haematological patients, pseudomonas aeruginosa, ORGANISMS::Bacteria::Gram-Negative Bacteria::Gram-Negative Aerobic Bacteria::Gram-Negative Aerobic Rods and Cocci::Pseudomonadaceae::Pseudomonas::Pseudomonas aeruginosa, Anti-Bacterial Agents, Malalts de càncer, Observational Studies as Topic, Infectious Diseases, Research Design, DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Leukocyte Disorders::Leukopenia::Agranulocytosis::Neutropenia, Pseudomonas aeruginosa, PHENOMENA AND PROCESSES::Microbiological Phenomena::Drug Resistance, Microbial, Tazobactam, Neutropenia, Pseudomones aeruginosa, multidrug-resistant, 610, bloodstream infection, Bloodstream infection, Pseudomonas, neutropenia, Humans, Pseudomonas Infections, Anti-Bacterial Agents/therapeutic use; Bacteremia/drug therapy; Bacteremia/mortality; Cephalosporins/therapeutic use; Drug Resistance, Multiple, Bacterial; Humans; International Cooperation; Logistic Models; Multicenter Studies as Topic; Neoplasms/complications; Neutropenia/complications; Observational Studies as Topic; Pseudomonas Infections/drug therapy; Pseudomonas aeruginosa/isolation & purification; Research Design; Retrospective Studies; Tazobactam/therapeutic use; Time Factors; bacteraemia; bloodstream infection; multidrug-resistant; neutropenia; onco-haematological patients; pseudomonas aeruginosa, Other subheadings::Other subheadings::Other subheadings::/immunology, ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas y micosis::infección::sepsis::bacteriemia, Resistència als medicaments, Retrospective Studies, DISEASES::Bacterial Infections and Mycoses::Bacterial Infections and Mycoses::Infection::Sepsis::Bacteremia, onco-haematological patients, Cancer patients, ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::trastornos leucocitarios::leucopenia::agranulocitosis::neutropenia, Cephalosporins, Otros calificadores::Otros calificadores::Otros calificadores::/inmunología, Logistic Models, Drug resistance, Bacteraemia, FENÓMENOS Y PROCESOS::fenómenos microbiológicos::farmacorresistencia microbiana

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	4
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average