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Recolector de Ciencia Abierta, RECOLECTA
Conference object . 2019
Data sources: Recolector de Ciencia Abierta, RECOLECTA
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Recolector de Ciencia Abierta, RECOLECTA
Conference object . 2020
Data sources: Recolector de Ciencia Abierta, RECOLECTA
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DIGITAL.CSIC
Conference object . 2020
Data sources: DIGITAL.CSIC
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Synthesis and characterization of new methotrexate derivatives containing divalent cations and their evaluation as bioactive compounds for musculoskeletal regeneration.

descriptionPublicationkeyboard_double_arrow_right Conference object 01 Jan 2019 Spain
Authors: Fernández-Villa, Daniel; Ramírez-Jiménez, Rosa Ana; Aranaz, Inmaculada; Acosta, Niuris; Vázquez Lasa, Blanca; Rojo del Olmo, Luis;

handle: 10261/210532

Synthesis and characterization of new methotrexate derivatives containing divalent cations and their evaluation as bioactive compounds for musculoskeletal regeneration.

Abstract

In the present work, methotrexate derivatives containing divalent cations (strontium, zinc and magnesium) were synthesized and characterized by different physicochemical techniques. In addition, strontium and zinc-derivatives biological activities were tested in vitro and encapsulated into chitosan microparticles as a both biocompatible and biodegradable system for their ulterior sustained release.

This work was supported by the Spanish program MICINN (MAT2015-73656-JIN) and CSIC program JAE Intro (JAEINT18-EX0511

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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