Co-localization of polar replication fork barriers and rRNA transcription terminators in mouse rDNA

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1998 English Publisher:Elsevier BVJournal:Journal of Molecular Biology, volume 277, pages 249-256 (issn: 0022-2836,

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Authors: López-Estraño, Carlos; Schvartzman, Jorge Bernardo; Krimer, Dora B.; Hernandez, Pablo;

doi: 10.1006/jmbi.1997.1607

pmid: 9514756

handle: 10261/210209

Co-localization of polar replication fork barriers and rRNA transcription terminators in mouse rDNA

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Abstract

We investigated the replication of the region where transcription terminates in mouse rDNA. It contains a replication fork barrier (RFB) that behaves in a polar manner, arresting only replication forks moving in the direction opposite to transcription. This RFB consists of several closely spaced fork arrest sites that co-localize with the transcription terminator elements, known as Sal boxes. Sal boxes are the target for mTTF-I (murine transcription termination factor I). These results suggest that both termination of rRNA transcription and replication fork arrest may share cis-acting as well as trans-acting factors.

Related Organizations

Spanish National Research Council
Spain

Keywords

DNA Replication, Terminator Regions, Genetic, Transcription termination, Thyroid Nuclear Factor 1, Replication fork barrier, Nuclear Proteins, Replication termination, DNA, Ribosomal, Mouse rDNA, Mice, RNA, Ribosomal, Tumor Cells, Cultured, Animals, Transcription Factors

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