Alterations in the mechanisms of control of microglial activation in Parkinson's disease: the CD200-CD200R1 system
Alterations in the mechanisms of control of microglial activation in Parkinson's disease: the CD200-CD200R1 system
Microglial cells are the resident immune cells of the CNS and act as sensors of neural activity. Neurons play a relevant role in maintaining microglial cells in a non-activated/surveilling state under physiological conditions, through a series of inhibitory mechanisms. However, chronic glial activation/neuroinflammation has been described in neurodegenerative diseases, suggesting that these mechanisms have been overloaded.
Supported by Instituto de Salud Carlos III, Spain-FEDER funds, EU (PI15/00033). NRL is a recipient of a FPU contract from the Spanish Ministerio de Ciencia, Innovación y Universidades.
Trabajo presentado en el XIV European Meeting on Glial Cells in Health and Disease, celebrado en Oporto (Portugal), del 10 al 13 de julio de 2019
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