Shotgun proteomics allow the study of the complete proteome without the need to work with isolated proteins. In this techniques, from the enzymatic digestion of the proteins contained in a biological sample can be carried out a massive analysis of the peptides obtained by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Because this technique allows a proteomic analysis from a wide range of biological samples, shotgun proteomics turns out to be highly interesting in the identification of biomarkers of mental disorders like Schizophrenia (SZ), where the affected tissue cannot be analysed in vivo and in which case the study is made from biological fluids such as blood

This work was supported by a Ramón & Cajal grant (RYC-2014-15246) and by Galicia Innovation Agency-GAIN grant (IN607D-2016/003; IN607D-2017/01).

Poster.-- 18th National Meeting of the Spanish Society in Neuroscience, September 4th, 2019 to September 6th, 2019, Santiago de Compostela

Peer reviewed