Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis

descriptionPublicationkeyboard_double_arrow_right Article 29 Mar 2019 Spain English Publisher:Springer Science and Business Media LLCJournal:BMC Infectious Diseases, volume 19 (eissn: 1471-2334,

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Authors: Ercibengoa, María; Goenaga Sánchez, Miguel Ángel; Ardanuy Tisaire, María Carmen; Grau, Immaculada; García de la Mària, Cristina; Almela, M. (Manel); Miró Meda, José M. (José María), 1956-; +13 Authors

doi: 10.1186/s12879-019-3914-6

pmid: 30922322

pmc: PMC6440093

handle: 10261/200444 , 20.500.12530/76790 , 10902/18964 , 2445/171684 , 10668/3164

Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis

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Abstract

Streptococcus tigurinus was recently described as a new streptococcal species within the viridans group streptococci (VGS). The objectives of the present work were to analyse the clinical and microbiological characteristics of S. tigurinus isolated from patients with bacteraemias, to determine the prevalence of S. tigurinus among VGS endocarditis in Spain, and to compare the clinical characteristics and outcomes of endocarditis caused by S. tigurinus and other VGS.Retrospective nationwide study, performed between 2008 and 2016 in 9 Spanish hospitals from 7 different provinces comprising 237 cases of infective endocarditis. Streptococcal isolates were identified by sequencing fragments of their 16S rRNA, sodA and groEL genes. Clinical data of patients with streptococcal endocarditis were prospectively collected according to a pre-established protocol.Patients with endocarditis represented 7/9 (77.8%) and 26/86 (30.2%) of the bacteraemias caused by S. tigurinus and other VGS, respectively (p < 0.001), in two of the hospital participants. Among patients with streptococcal endocarditis, 12 different Streptococcus species were recognized being S. oralis, S. tigurinus and S. mitis the three more common. No relevant statistical differences were observed in the clinical characteristics and outcomes of endocarditis caused by the different VGS species.In this multicenter study performed in Spain, S. tigurinus showed a higher predilection for the endocardial endothelium as compared to other VGS. However, clinical characteristics and outcomes of endocarditis caused by S. tigurinus did not significantly differ from endocarditis caused by other oral streptococci.

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Keywords

Male, Epidemiology, Antibiotic resistance, Bacteremia, Infectious and parasitic diseases, RC109-216, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Diagnòstic, Risk Factors, Diagnosis, Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Bacteremia, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiological Monitoring, Aged, 80 and over, Endocarditis, Streptococcus Viridans, Middle Aged, Prognosis, Viridans Streptococci, Infeccions, Medical Subject Headings::Check Tags::Male, Epidemiologic surveillance, Epidemiological Monitoring, Female, Medical Subject Headings::Persons::Persons::Age Groups::Adult, Research Article, Adult, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors, Medical Subject Headings::Persons::Persons::Age Groups::Adult::Young Adult, Multicentre studies, Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Endocarditis, Bacterial, Infections, Young Adult, Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged, Streptococcal Infections, Humans, Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and over, Medical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Gram-Positive Cocci::Streptococcaceae::Streptococcus::Viridans Streptococci, Epidemiologia, Aged, Retrospective Studies, Antibiotic, Medical Subject Headings::Check Tags::Female, Endocarditis, Bacterial, Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain, Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Streptococcal Infections, Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged, Spain, Infective endocarditis, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies

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