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Epidemiology of antibiotic resistance in Pseudomonas aeruginosa. Implications for empiric and definitive therapy.

Authors: Ruiz-Garbajosa, Patricia; Cantón, Rafael;

Epidemiology of antibiotic resistance in Pseudomonas aeruginosa. Implications for empiric and definitive therapy.

Abstract

Pseudomonas aeruginosa is one of the major pathogens causing hospital-acquired infections. It can easily develop antibiotic resistance through chromosomal mutations or by horizontal acquisition of resistant determinants. The increasing prevalence of multi-drug-resistant (MDR) or extensively-drugresistant (XDR) P. aeruginosa isolates is associated with the dissemination of the so-called high-risk-clones, such as ST175. Infections caused by MDR/XDR are a cause of concern as they compromise the selection of appropriate empiric and definitive antimicrobial treatments. Introduction of new antibiotics with potent activity against MDR/XDR P. aeruginosa opens new horizons in the treatment of these infections.

Pseudomonas aeruginosa es uno de los principales patógenos nosocomiales. Presenta una gran capacidad para desarrollar resistencias, bien por mutaciones cromosómicas o por adquisición de genes localizados en elementos transferibles. La emergencia de P. aeruginosa multirresistente (MR) y extremadamente resistente (XR) se ha asociado con la diseminación de los denominados clones de alto riesgo, como el ST175. Las infecciones causadas por estos clones comprometen la adecuación del tratamiento antimicrobiano empírico y definitivo. La introducción de nuevos antibióticos con potente actividad frente a P. aeruginosa MR/XR abre nuevos horizontes en el tratamiento de estas infecciones.

RC has participate in educational programs organized by AstraZeneca and MSD and had a research project founded by Cubist.

Keywords

Multirresistencia, Cross Infection, Ceftolozane-tazobactam, Multidrug-resistance, Anti-Bacterial Agents, P. aeruginosa, Drug Resistance, Multiple, Bacterial, Drug Resistance, Bacterial, Pseudomonas aeruginosa, Humans, Pseudomonas Infections

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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