Hydrophobic peptide interactions with phospholipids

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2004 English Publisher:Elsevier BVJournal:Colloids and Surfaces A: Physicochemical and Engineering Aspects, volume 249, pages 15-18 (issn: 0927-7757,

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Authors: Reig Isart, Francesca; Juvé, A.; Sospedra, Patricia; Rodríguez, L.;

doi: 10.1016/j.colsurfa.2004.08.075

handle: 10261/19125

Hydrophobic peptide interactions with phospholipids

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Abstract

To his end surface activity at different pH values, insertion in dipalmitoyl phosphatidylcholine (DPPC) and dipalmitoyl phosphatidylglycerol (DPPG) were determined. This peptide forms stable monolayers and is able to insert in neutral and anionic films. Miscibility studies with DPPC show positive deviations from ideality at 0.6–0.8 DPPC molar fractions.

A short peptide related to SIKVAK laminin active sequence was derivatised with a estearoyl residue. This hydrophobic peptide was characterised as far as its physicochemical properties were concerned.

4 pages, 4 figures, 2 tables.-- Printed version published Nov 30, 2004.-- Issue title: "1st International Meeting on Applied Physics (Badajoz, Spain, Oct 15-18, 2003).

This work was financially supported by a SAF 97-0174 grant.

Peer reviewed

Related Organizations

University of Barcelona
Spain

Keywords

Monolayers, Peptide synthesis, Laminin, Phospholipids

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