Comparison of clinical categories for Escherichia coli harboring specific qnr and chromosomal-mediated fluoroquinolone resistance determinants according to CLSI and EUCAST

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2016 English Publisher:Elsevier BVJournal:Enfermedades Infecciosas y Microbiología Clínica, volume 34, pages 188-190 (issn: 0213-005X,

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Authors: Jesús, Machuca; Alejandra, Briales; Paula, Díaz-de-Alba; Luis, Martínez-Martínez; José-Manuel, Rodríguez-Martínez; Álvaro, Pascual;

doi: 10.1016/j.eimc.2015.01.019

pmid: 25772329

handle: 10261/184778

Comparison of clinical categories for Escherichia coli harboring specific qnr and chromosomal-mediated fluoroquinolone resistance determinants according to CLSI and EUCAST

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Abstract

EUCAST breakpoints are more restrictive than those defined by CLSI. This study highlights the discrepancies between CLSI and EUCAST in a well characterized isogenic Escherichia coli collection and their correlations with specific quinolone resistance mechanisms. The greatest number of discrepancies was observed in strains containing 2-4 resistance mechanisms (MIC values on the borderline of clinical resistance). Bearing in mind that quinolones are concentration dependent antimicrobial agents, small changes in MIC may have relevant consequences for treatment outcomes.

Related Organizations

University of Seville
Spain
Hospital Universitario Virgen Macarena
Spain
University of Cantabria
Spain
Instituto de Salud Carlos III
Spain
Marqués de Valdecilla University Hospital
Spain

Keywords

Quinolone, Resistance, qnr, Microbial Sensitivity Tests, Anti-Bacterial Agents, Resistencia, Drug Resistance, Bacterial, Quinolonas, Escherichia coli, Humans, CLSI, EUCAST, Fluoroquinolones

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