The progressive increase in life expectancy has led to an increase in the incidence of age-related diseases, including Alzheimer’s disease (AD). Currently there are no effective treatments against AD, therefore, the search for preventive treatments is of great interest to achieve healthy aging. We hypothesize that the activation of anti-aging molecular pathways may induce a preventive effect of cellular resilience against the development of AD pathological processes. We evaluated the proposed anti-aging compounds resveratrol and melatonin by diet supplementation in 3xTgAD and control healthy NoTg mice. Both compounds activated the neuroprotective and longevity SIRT1 pathway. The changes in 3xTg-AD hippocampus included decline of Aβ and tau pathology, decrease of inflammatory markers that suggests a protection against inflammaging, increase of proteolytic mechanism against aberrant proteins, and beneficial changes in mitochondrial function and plasticity processes. Remarkably, these treatments induced upregulation of neuroprotective mechanisms in the healthy NoTg mice. Both resveratrol and melatonin protected against memory loss in 3xTg-AD and induced improved behavior in the healthy mice. Our data confirmed the potential of both anti-aging compounds to induce neuroprotection against AD-pathology, and unveiled their preventive effects by increasing brain resilience

Trabajo presentado en el XI Simposi de Neurobiologia: Future technical advances, organizado por la Socitat Catalana de Biologia, en Barcelona, los días 12 y 13 de noviembre de 2018

Peer reviewed