Downloads provided by UsageCountsTargeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalk
Copyright policy ) Carlos A. Orozco; Neus Martinez-Bosch; Pedro E. Guerrero; Judith Vinaixa; Tomás Dalotto-Moreno; Mar Iglesias; Mireia Moreno; +8 Authors
Carlos A. Orozco; Neus Martinez-Bosch; Pedro E. Guerrero; Judith Vinaixa; Tomás Dalotto-Moreno; Mar Iglesias; Mireia Moreno; Magdolna Djurec; Françoise Poirier; Hans-Joachim Gabius; Martin E. Fernandez-Zapico; Rosa F. Hwang; Carmen Guerra; Gabriel A. Rabinovich; Pilar Navarro;
Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalk
Significance Pancreatic ductal adenocarcinoma (PDA) is the third leading of cause of cancer death in the United States and is predicted to be the second one by 2030. The tumor microenvironment is a major source of soluble mediators that influence tumor progression and hinder the success of therapeutic strategies. Using a genetically engineered mouse model and human cell-based systems, we identify galectin-1 (Gal1) as a critical soluble factor capable of regulating tumor–stroma crosstalk promoting proliferation, angiogenesis, and modulation of inflammatory responses, resulting in enhanced tumor development and metastasis. Our data provide an integrated view of the role of Gal1 in the PDA microenvironment and reinforce the high therapeutic value of Gal1 inhibition in PDA treatment.
Argentina, Spain, Spain, Spain
Galectin 1, PANCREATIC STELLATE CELLS, Antioxidants, Mice, Cell Movement, https://purl.org/becyt/ford/3.1, Galectin-1, Tumor immunity, Tumor Microenvironment, Molecular Targeted Therapy, RNA, Small Interfering, Neoplasm Metastasis, Hypoxia, Mice, Knockout, Pancreatic stellate cells, Neovascularization, Pathologic, Q, Pancreatic Stellate Cells, R, Phenylethyl Alcohol, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, PANCREATIC CANCER, Gene Expression Regulation, Neoplastic, Tumor microenvironment, Receptors, Estrogen, Gene Knockdown Techniques, MCF-7 Cells, Medicine, Heterografts, TUMOR MICROENVIRONMENT, Cell Division, Research Article, Signal Transduction, Carcinoma, Pancreatic Ductal, NF-E2-Related Factor 2, Science, Galectins, Breast Neoplasms, Mice, Transgenic, Lymphocytes, Tumor-Infiltrating, Cell Line, Tumor, Paracrine Communication, Animals, Humans, TUMOR IMMUNITY, https://purl.org/becyt/ford/3, RNA, Messenger, Olive Oil, ERRalpha Estrogen-Related Receptor, Pancreatic cancer, GALECTIN-1, Pancreatic Neoplasms, Oxidative Stress, Gene Ontology, Culture Media, Conditioned, Stromal Cells, Reactive Oxygen Species
Galectin 1, PANCREATIC STELLATE CELLS, Antioxidants, Mice, Cell Movement, https://purl.org/becyt/ford/3.1, Galectin-1, Tumor immunity, Tumor Microenvironment, Molecular Targeted Therapy, RNA, Small Interfering, Neoplasm Metastasis, Hypoxia, Mice, Knockout, Pancreatic stellate cells, Neovascularization, Pathologic, Q, Pancreatic Stellate Cells, R, Phenylethyl Alcohol, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, PANCREATIC CANCER, Gene Expression Regulation, Neoplastic, Tumor microenvironment, Receptors, Estrogen, Gene Knockdown Techniques, MCF-7 Cells, Medicine, Heterografts, TUMOR MICROENVIRONMENT, Cell Division, Research Article, Signal Transduction, Carcinoma, Pancreatic Ductal, NF-E2-Related Factor 2, Science, Galectins, Breast Neoplasms, Mice, Transgenic, Lymphocytes, Tumor-Infiltrating, Cell Line, Tumor, Paracrine Communication, Animals, Humans, TUMOR IMMUNITY, https://purl.org/becyt/ford/3, RNA, Messenger, Olive Oil, ERRalpha Estrogen-Related Receptor, Pancreatic cancer, GALECTIN-1, Pancreatic Neoplasms, Oxidative Stress, Gene Ontology, Culture Media, Conditioned, Stromal Cells, Reactive Oxygen Species
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).166 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1% views 114 downloads 89 - 114views89downloads
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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