Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

descriptionPublicationkeyboard_double_arrow_right Article 07 Jun 2017 Switzerland, United Kingdom, Belgium, United Kingdom, France, France, Spain, United States, Netherlands English Publisher:Oxford University Press (OUP)Journal:Journal of Neuropathology & Experimental Neurology, volume 76, pages 605-619 (issn: 0022-3069, eissn: 1554-6578,

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Authors: Kovacs, Gabor; Xie, Sharon; Lee, Edward; Robinson, John; Caswell, Carrie; Irwin, David; Toledo, Jon; +55 Authors

doi: 10.1093/jnen/nlx041

pmid: 28591867

pmc: PMC6251511

handle: 10261/176732 , 2445/124277 , 2445/162098 , 1983/6d141c92-4d03-4114-8ec3-a7a78cd4cdb3 , 10044/1/50654

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

- Summary
- Subjects
- Metrics

Abstract

Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was >60% with a kappa value of 0.55 (95% CI 0.433-0.645). Moderate agreement (>90%, kappa 0.48, 95% CI 0.457-0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37-0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341-0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534-0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.

Countries

Switzerland, United Kingdom, Belgium, United Kingdom, France, France, Spain, United States, Netherlands

Related Organizations

ZEN University
Japan
University of California, Davis
United States
University of Sydney
Australia
University of Toronto
Canada
Inserm
France

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Keywords

Male, Aging, NEUROPATHOLOGIC CRITERIA, Astròcits, Neurodegenerative, Alzheimer's Disease, GUIDELINES, ASTROCYTES, Severity of Illness Index, name=Cerebrovascular and Dementia Research Group, 80 and over, Pathology, ARGYROPHILIC GRAIN DISEASE, Neuropathology, Aged, 80 and over, Envelliment cerebral, Malalties neurodegeneratives, Tau-astrogliopathy, Neurodegenerative Diseases, DEGENERATION, Middle Aged, ALZHEIMERS-DISEASE, Frontotemporal Dementia (FTD), Tauopathies, AGREEMENT, Aging brain, Female, Life Sciences & Biomedicine, NEUROFIBRILLARY PATHOLOGY, Clinical Sciences, Clinical Neurology, tau Proteins, Malalties del sistema nerviós, Envelliment, 616, Acquired Cognitive Impairment, Digital pathology, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Aged, Science & Technology, Neurology & Neurosurgery, Interrater agreement, 3202 Clinical sciences, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), ARTAG, 1103 Clinical Sciences, Nervous system Diseases, PROGRESSIVE SUPRANUCLEAR PALSY, Nervous system diseases, Brain Disorders, /dk/atira/pure/core/keywords/dementia_research_group; name=Cerebrovascular and Dementia Research Group, 616.89, Astrocytes, 3209 Neurosciences, Dementia, BRAINNET EUROPE CONSORTIUM, Neurosciences & Neurology, Tau, 1109 Neurosciences, /dk/atira/pure/core/keywords/dementia_research_group, ddc: ddc:616.89

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